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Professor Philip Hogg

Contact Details

Phone: 51004
Email: p.hogg@unsw.edu.au

Bio

Research Interests:
Protein disulphide bonds are the links between the sulphur atoms of two cysteine amino acids. All life forms make this bond. Disulphide bonds perform either a structural or functional role in the mature protein. There are two types of functional disulphide: the catalytic and allosteric bonds. The catalytic bonds are found at the active sites of the oxidoreductases. The allosteric disulphide bonds, which were identified and have been defined by Prof Hogg, control the function of the protein in which they reside by mediating a change when they are reduced or oxidized. Their characterisation will lead to a better understanding of not only mammalian biology, but also the biology of viral and bacterial pathogens. Healthy cells mainly rely on oxidative phosphorylation to catabolise nutrients, while cancer cells employ aerobic glycolysis. Mitochondria coordinate the catabolism of nutrients across the cancer cell.

Prof Hogg has made novel, small-molecule inhibitors of mitochondrial adenine nucleotide translocase (ANT), GSAO and PENAO, that are currently being trialled in patients with solid tumours. Cystemix Pty Ltd was formed to manage the commercial development of this suite of drugs. Prof Hogg has invented an effective small molecule non-invasive imaging agent for dying and dead cells. This technology will have many applications both in the research arena and in clinical practice. Its most obvious clinical utility is for monitoring cancer therapy.

Broad Research Areas: Biochemistry
       
Specific Research Keywords:   
Allosteric Disulphides, Protein Regulation, Cancer Drug Development and Pharmacology

Awards and Honours:

  • R. Douglas Wright Fellowship, National Health and Medical Research Council of Australia (1993)
  • Senior Research Fellowship, National Health and Medical Research Council of Australia (1996)
  • The Speywood Medal, Australian Society for Thrombosis and Haemostasis (1996)
  • Principal Research Fellowship, National Health and Medical Research Council of Australia (2000)
  • Commonwealth Health Minister's Award for Excellence in Health and Medical Research (2001)
  • GlaxoSmithKline Australia Award for Research Excellence (formally Wellcome Medal) (2001)
  • The GE Healthcare Bio-Sciences Award, Australian Society for Biochemistry and Molecular Biology (2006)
  • NSW Scientist of the Year: Biomedical Sciences Category (2008)
  • Cancer Institute NSW Premier’s Award for Outstanding Cancer Researcher (2009)
  • Oscar Ratnoff Award, International Society on Thrombosis and Haemostasis (2009)
  • Jamie Callachor Eureka Prize for Medical Research Translation (2010)

Funding Sources:

  • Cancer Institute NSW, Australia
    PJ Hogg, RL Ward, IW Dawes, RB Lock, P de Souza; Cancer Institute NSW Translational Program Grant; Anti-mitochondrial cancer drugs; 2007-2011; $3,750,000
    Pre-clinical and clinical investigations of PENAO, which is a tumor metabolism inhibitor that inactivates adenine nucleotide translocase of the inner-mitochondrial membrane. Prof Hogg oversees all aspects of the research program.
  • Cancer Council NSW, Australia
    PJ Hogg, PJ Dilda; Cancer Council NSW Program Grant PG 11-03; Metabolism inhibitors for the treatment of brain and pancreatic cancer; 2011-2015; $2,250,000
    Discovery and development of novel tumor metabolism inhibitors that target adenine nucleotide translocase of the inner-mitochondrial membrane. Prof Hogg oversees all aspects of the research program.
  • National Health & Medical Research Council, Australia
    PJ Hogg; NHMRC Senior Principal Research Fellowship 1002645; 2011-2015; $855,805 Salary support    

Thesis topics for current UNSW Medicine postgraduate research students

  • A method for selective enrichment and analysis of the nitrotyrosine proteome in lung cancer
  • A method for selective enrichment and analysis of the nitrotyrosine proteome in lung cancer
  • Pre-clinical development of a novel anti-mitochondrial cancer drug.

 

University role

Snr Principal Res Fell NH&MRC

Location

Prince of Wales Clinical School

Publications