Browse Research Interests

Ageing
Allergy
Bioethics
Biomedical Engineering
Biostatistics
Cancer
Cardiology and Vascular Disease
Cell Biology and Gene Regulation
Clinical Governance
Clinical Research
Diabetes
Epidemiology
Evidence Based Medicine
Gastrointestinal Diseases
Genetics - Genome Analysis
Gerontology - Geriatrics
Global Health
Haematology
	Dr John Pimanda     Prince of Wales Clinical School Statement of Interests: Haematopoietic Stem Cells (HSCs) represent the best characterized adult multipotent stem cell population. Transcriptional regulation is a key mechanism controlling the formation and subsequent behaviour of HSCs. To investigate gene regulatory networks that operate during HSC specification, we use computational tools to predict regulatory elements of key haematopoietic transcription factor genes. We then filter these predictions using array based chromatin accessibility and transcription factor binding profiles. Transgenic mice are generated to test whether these predicted elements show tissue specific activity in the developing embryo. We also investigate mesenchymal stem/progenitor cell (MSCs)development to compare and contrast gene transcription between HSCs and MSCs. Knowledge of the normal transcriptional hierarchies of these cell types can be applied to better understand the dysregulation of these networks in the pathogenesis of cancer. To this end, we also study the biology of blood stem cell dyscrasias with a particular focus on the myelodysplastic and myeloproliferative syndromes. More...
Health Policy
Health Services Research
HIV - AIDS
Imaging / Radiology
Immunology
Infectious Diseases
Inflammation
Injury
Medical Education
Medical Informatics
Metabolism
Molecular Structure & Drug Design
Neurodegenerative Diseases
Neurology
Neuroscience
Ophthalmology
Orthopaedics
Pain
Pathology
Pharmacology
Physiology
Population Health
Preventive Medicine
Primary Health Care
Pulmonary Disease
Rehabilitation
Renal Disease
Stem Cells
Surgery
Toxicology
Transplantation
Virology