Wnt Signalling & Metastasis
Our overall aim is to understand the key processes in epithelial to mesenchymal transition (EMT) and metastasis, in order to identify targets for novel cancer therapies.
Our group focuses on an important signalling pathway involved in metastasis and EMT, the Wnt signalling pathway. We are particularly interested in investigating the epigenetic regulation of a number of key proteins involved in this pathway, and understanding their role in the context of ovarian, breast and colorectal cancer.
Grants & Funding
2012: UNSW Faculty Research Grant - $20,000. The role of the Ror2 Wnt receptor tyrosine kinase in colorectal cancer
2011: Cure Cancer Australia Grant #1008633 - $90,000. Targeting the Wnt signalling pathway - a new metastatic and epigenetic therapy for ovarian cancer
2010-2012: NHMRC Project Grant #630458 - $318,750 . Wnt-5a signaling – a novel therapy for triple negative and Tamoxifen resistant breast cancer patients
2007-2011: NHMRC CJ Martin Fellowship #466005 - $314,589