Dr Jason Wong

Krilis M; Qi M; Qi J; Wong JWH; Guymer R; Liew G; Hunyor AP; Madigan M; McCluskey P; Weaver J, 2018, 'Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration', Free Radical Biology and Medicine, vol. 129, pp. 237 - 246, http://dx.doi.org/10.1016/j.freeradbiomed.2018.09.034

Liu Q; Thoms JAI; Nunez AC; Huang Y; Knezevic K; Packham D; Poulos RC; Williams R; Beck D; Hawkins NJ, 2018, 'Disruption of a 35 KB enhancer impairs CTCF binding and MLH1 expression in colorectal cells', Clinical Cancer Research, vol. 24, pp. 4602 - 4611, http://dx.doi.org/10.1158/1078-0432.CCR-17-3678

Pijning AE; Chiu J; Yeo RX; Wong JWH; Hogg PJ, 2018, 'Identification of allosteric disulfides from labile bonds in X-ray structures', Royal Society Open Science, vol. 5, http://dx.doi.org/10.1098/rsos.171058

Beck D; Thoms JAI; Palu C; Herold T; Shah A; Olivier J; Boelen L; Huang Y; Chacon D; Brown A, 2018, 'A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients', Leukemia, vol. 32, pp. 263 - 272, http://dx.doi.org/10.1038/leu.2017.210

Ma S; Menon R; Poulos RC; Wong JWH, 2017, 'Proteogenomic analysis prioritises functional single nucleotide variants in cancer samples', Oncotarget, vol. 8, pp. 95841 - 95852, http://dx.doi.org/10.18632/oncotarget.21339

Schwarzer A; Emmrich S; Schmidt F; Beck D; Ng M; Reimer C; Adams FF; Grasedieck S; Witte D; Käbler S, 2017, 'The non-coding RNA landscape of human hematopoiesis and leukemia', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-00212-4

Poulos RC; Olivier J; Wong JWH, 2017, 'The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes', Nucleic Acids Research, vol. 45, pp. 7786 - 7795, http://dx.doi.org/10.1093/nar/gkx463

Krilis M; Qi M; Madigan MC; Wong JWH; Abdelatti M; Guymer RH; Whitelock J; McCluskey P; Zhang P; Qi J, 2017, 'Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration', Oncotarget, vol. 8, pp. 49016 - 49032, http://dx.doi.org/10.18632/oncotarget.14940

Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V, 2017, 'Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes', Cell Reports, vol. 20, pp. 572 - 585, http://dx.doi.org/10.1016/j.celrep.2017.06.067

Wong M; Tee AEL; Milazzo G; Bell JL; Poulos RC; Atmadibrata B; Sun Y; Jing D; Ho N; Ling D, 2017, 'The histone methyltransferase DOT1L promotes neuroblastoma by regulating gene transcription', Cancer Research, vol. 77, pp. 2522 - 2533, http://dx.doi.org/10.1158/0008-5472.CAN-16-1663

Zeraati M; Moye AL; Wong JWH; Perera D; Cowley MJ; Christ DU; Bryan TM; Dinger ME, 2017, 'Cancer-Associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expression', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-00739-y

Nasrallah R; Fast EM; Solaimani P; Knezevic K; Eliades A; Patel R; Thambyrajah R; Unnikrishnan A; Thoms J; Beck D, 2016, 'Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes', Blood, vol. 128, pp. 1928 - 1939, http://dx.doi.org/10.1182/blood-2016-02-697870

Unnikrishnan A; Guan YF; Huang Y; Beck D; Thoms JAI; Peirs S; Knezevic K; Ma S; De Walle IV; De Jong IDE, 2016, 'A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network', Nucleic Acids Research, vol. 44, pp. 10644 - 10661, http://dx.doi.org/10.1093/nar/gkw804

Poulos RC; Wong JWH, 2016, 'Mutation hotspots in cis-regulatory regions in cancer', Oncoscience, vol. 3, pp. 318 - 319, http://dx.doi.org/10.18632/oncoscience.325

Hesson LB; Ng B; Zarzour P; Srivastava S; Kwok CT; Packham D; Nunez AC; Beck D; Ryan R; Dower A, 2016, 'Integrated genetic, epigenetic, and transcriptional profiling identifies molecular pathways in the development of laterally spreading tumors', Molecular Cancer Research, vol. 14, pp. 1217 - 1228, http://dx.doi.org/10.1158/1541-7786.MCR-16-0175

Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A, 2016, 'Pdgf-ab and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113

Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, vol. 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15

Srivastava S; Ludwig AK; Wong JWH; Hesson LB, 2016, 'An investigation of the potential for epigenetic inactivation by transcription read-through in a sporadic colorectal cancer', Gene, vol. 585, pp. 154 - 158, http://dx.doi.org/10.1016/j.gene.2016.03.031

Huang Y; Thoms JAI; Tursky ML; Knezevic K; Beck D; Chandrakanthan V; Suryani S; Olivier J; Boulton A; Glaros EN, 2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, vol. 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55

Perera D; Poulos RC; Shah A; Beck D; Pimanda JE; Wong JWH, 2016, 'Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes.', Nature, vol. 532, pp. 259 - 263, http://dx.doi.org/10.1038/nature17437

Sun Y; Bell JL; Carter D; Gherardi S; Poulos RC; Milazzo G; Wong JWH; Al-Awar R; Tee AE; Liu PY, 2015, 'WDR5 supports an N-myc transcriptional complex that drives a protumorigenic gene expression signature in neuroblastoma', Cancer Research, vol. 75, pp. 5143 - 5154, http://dx.doi.org/10.1158/0008-5472.CAN-15-0423

Poulos RC; Sloane MA; Hesson LB; Wong JWH, 2015, 'The search for cis-regulatory driver mutations in cancer genomes', Oncotarget, vol. 6, pp. 32509 - 32525, http://dx.doi.org/10.18632/oncotarget.5085

Ma S; Downard KM; Wong JWH, 2015, 'FluClass: A novel algorithm and approach to score and visualize the phylogeny of the influenza virus using mass spectrometry', Analytica Chimica Acta, vol. 895, pp. 54 - 61, http://dx.doi.org/10.1016/j.aca.2015.09.004

Poulos RC; Thoms JAI; Shah A; Beck D; Pimanda JE; Wong JWH, 2015, 'Systematic screening of promoter regions pinpoints functional cis-regulatory mutations in a cutaneous melanoma genome', Molecular Cancer Research, vol. 13, pp. 1218 - 1226, http://dx.doi.org/10.1158/1541-7786.MCR-15-0146

Zarzour P; Boelen L; Luciani F; Beck D; Sakthianandeswaren A; Mouradov D; Sieber OM; Hawkins NJ; Hesson LB; Ward RL, 2015, 'Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas', Genes Chromosomes and Cancer, vol. 54, pp. 303 - 314, http://dx.doi.org/10.1002/gcc.22243

Hesson LB; Packham D; Kwok C-T; Nunez AC; Ng B; Schmidt C; Fields M; Wong JWH; Sloane MA; Ward RL, 2015, 'Lynch syndrome associated with two MLH1 promoter variants and allelic imbalance of MLH1 expression.', Hum Mutat, vol. 36, pp. 622 - 630, http://dx.doi.org/10.1002/humu.22785

Ng JY; Wong JWH, 2015, 'Bioorthogonal labelling of 3-nitrotyrosine in peptides and proteins through diazotisation mediated azidation', Organic and Biomolecular Chemistry, vol. 13, pp. 374 - 378, http://dx.doi.org/10.1039/c4ob02133a

Jing D; Bhadri VA; Beck D; Thoms JAI; Yakob NA; Wong JWH; Knezevic K; Pimanda JE; Lock RB, 2015, 'Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells.', Blood, vol. 125, pp. 273 - 283, http://dx.doi.org/10.1182/blood-2014-05-576470

Tursky ML; Beck D; Thoms JAI; Huang Y; Kumari A; Unnikrishnan A; Knezevic K; Evans K; Richards LA; Lee E, 2015, 'Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias.', Leukemia, vol. 29, pp. 819 - 827, http://dx.doi.org/10.1038/leu.2014.299

Hesson LB; Sloane MA; Wong JWH; Nunez AC; Srivastava S; Ng B; Hawkins NJ; Bourke MJ; Ward RL, 2014, 'Altered promoter nucleosome positioning is an early event in gene silencing', Epigenetics, vol. 9, pp. 1422 - 1430, http://dx.doi.org/10.4161/15592294.2014.970077

Perera D; Chacon D; Thoms JAI; Poulos RC; Shlien A; Beck D; Campbell PJ; Pimanda JE; Wong JWH, 2014, 'OncoCis: annotation of cis-regulatory mutations in cancer', Genome Biology, vol. 15, http://dx.doi.org/10.1186/s13059-014-0485-0

Sloane MA; Wong JWH; Perera D; Nunez AC; Pimanda JE; Hawkins NJ; Sieber OM; Bourke MJ; Hesson LB; Ward RL, 2014, 'Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia', Epigenetics, vol. 9, pp. 1092 - 1100, http://dx.doi.org/10.4161/epi.29222

Chiu J; Wong JWH; Hogg PJ, 2014, 'Redox regulation of Methionine aminopeptidase 2 activity', Journal of Biological Chemistry, vol. 289, pp. 15035 - 15043, http://dx.doi.org/10.1074/jbc.M114.554253

Butera D; Cook KM; Chiu J; Wong JWH; Hogg PJ, 2014, 'Control of blood proteins by functional disulfide bonds.', Blood, vol. 123, pp. 2000 - 2007, http://dx.doi.org/10.1182/blood-2014-01-549816

Chiu J; Wong JWH; Gerometta M; Hogg PJ, 2014, 'Mechanism of dimerization of a recombinant mature vascular endothelial growth factor C', Biochemistry, vol. 53, pp. 7 - 9, http://dx.doi.org/10.1021/bi401518b

Chacon D; Beck D; Perera D; Wong JWH; Pimanda JE, 2014, 'BloodChIP: A database of comparative genome-wide transcription factor binding profiles in human blood cells', Nucleic Acids Research, vol. 42, http://dx.doi.org/10.1093/nar/gkt1036

Lun ATL; Swaminathan K; Wong JWH; Downard KM, 2013, 'Mass trees: a new phylogenetic approach and algorithm to chart evolutionary history with mass spectrometry.', Anal Chem, vol. 85, pp. 5475 - 5482, http://dx.doi.org/10.1021/ac4005875

Beck D; Thoms JAI; Perera D; Schütte J; Unnikrishnan A; Knezevic K; Kinston SJ; Wilson NK; O'Brien TA; Göttgens B, 2013, 'Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes', Blood, vol. 122, pp. e12 - e22, http://dx.doi.org/10.1182/blood-2013-03-490425

Ng JY; Boelen L; Wong JWH, 2013, 'Bioinformatics analysis reveals biophysical and evolutionary insights into the 3-nitrotyrosine post-translational modification in the human proteome.', Open Biol, vol. 3, pp. 120148, http://dx.doi.org/10.1098/rsob.120148

Ng JY; Chiu J; Hogg PJ; Wong JWH, 2013, 'Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2', Biochemical and Biophysical Research Communications, vol. 440, pp. 37 - 42, http://dx.doi.org/10.1016/j.bbrc.2013.09.035

Diffner E; Beck D; Gudgin E; Thoms JAI; Knezevic K; Pridans C; Foster S; Goode D; Lim WK; Boelen L, 2013, 'Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia.', Blood, vol. 121, pp. 2289 - 2300, http://dx.doi.org/10.1182/blood-2012-07-446120

Wong JJL; Ritchie W; Ebner OA; Selbach M; Wong JWH; Huang Y; Gao D; Pinello N; Gonzalez M; Baidya K, 2013, 'Orchestrated intron retention regulates normal granulocyte differentiation', Cell, vol. 154, pp. 583 - 595, http://dx.doi.org/10.1016/j.cell.2013.06.052

Lun AT; Wong JW; Downard KM, 2012, 'FluShuffle and FluResort: new algorithms to identify reassorted strains of the influenza virus by mass spectrometry.', BMC Bioinformatics, vol. 13, pp. 208, http://dx.doi.org/10.1186/1471-2105-13-208

Giannakopoulos B; Gao L; Qi M; Wong JW; Yu DM; Vlachoyiannopoulos PG; Moutsopoulos HM; Atsumi T; Koike T; Hogg P, 2012, 'Factor XI is a substrate for oxidoreductases: enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis.', J Autoimmun, vol. 39, pp. 121 - 129, http://dx.doi.org/10.1016/j.jaut.2012.05.005

Wong JWH; Abuhusain HJ; McDonald KL; Don AS, 2012, 'MMSAT: automated quantification of metabolites in selected reaction monitoring experiments.', Anal Chem, vol. 84, pp. 470 - 474, http://dx.doi.org/10.1021/ac2026578

Beck D; Brandl MB; Boelen L; Unnikrishnan A; Pimanda JE; Wong JWH, 2012, 'Signal analysis for genome-wide maps of histone modifications measured by ChIP-seq.', Bioinformatics, vol. 28, pp. 1062 - 1069, http://dx.doi.org/10.1093/bioinformatics/bts085

Azimi I; Wong JWH; Hogg PJ, 2011, 'Control of mature protein function by allosteric disulfide bonds', Antioxidants and Redox Signaling, vol. 14, pp. 113 - 126, http://dx.doi.org/10.1089/ars.2010.3620

Wong JWH; Ho SYW; Hogg PJ, 2011, 'Disulfide bond acquisition through eukaryotic protein evolution', Molecular Biology and Evolution, vol. 28, pp. 327 - 334, http://dx.doi.org/10.1093/molbev/msq194

Park D; Don AS; Massamiri T; Karwa A; Warner B; MacDonald J; Hemenway C; Naik A; Kuan KT; Dilda PJ, 2011, 'Noninvasive imaging of cell death using an Hsp90 ligand', Journal of the American Chemical Society, vol. 133, pp. 2832 - 2835, http://dx.doi.org/10.1021/ja110226y

Thoms JAI; Birger Y; Foster S; Knezevic K; Kirschenbaum Y; Chandrakanthan V; Jonquieres G; Spensberger D; Wong JW; Oram SH, 2011, 'ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer', Blood, vol. 117, pp. 7079 - 7089, http://dx.doi.org/10.1182/blood-2010-12-317990

Ganderton T; Wong JWH; Schroeder C; Hogg PJ, 2011, 'Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain', Blood, vol. 118, pp. 5312 - 5318, http://dx.doi.org/10.1182/blood-2011-06-360297

Hejazi L; Wong JWH; Cheng D; Proschogo N; Ebrahimi D; Garner B; Don AS, 2011, 'Mass and relative elution time profiling: Two-dimensional analysis of sphingolipids in Alzheimer's disease brains', Biochemical Journal, vol. 438, pp. 165 - 175, http://dx.doi.org/10.1042/BJ20110566

Porro A; Haber M; Diolaiti D; Iraci N; Henderson M; Gherardi S; Valli E; Munoz MA; Xue C; Flemming C, 2010, 'Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer', J Biol Chem, vol. 285, pp. 19532 - 19543, http://dx.doi.org/10.1074/jbc.M109.078584

Schwahn AB; Wong JWH; Downard KM, 2010, 'Rapid differentiation of seasonal and pandemic H1N1 influenza through proteotyping of viral neuraminidase with mass spectrometry.', Anal Chem, vol. 82, pp. 4584 - 4590, http://dx.doi.org/10.1021/ac100594j

Schwahn AB; Wong JWH; Downard KM, 2010, 'Rapid typing and subtyping of vaccine strains of the influenza virus with high resolution mass spectrometry.', Eur J Mass Spectrom (Chichester), vol. 16, pp. 321 - 329, http://dx.doi.org/10.1255/ejms.1056

Wong JWH; Hogg PJ, 2010, 'Analysis of disulfide bonds in protein structures.', J Thromb Haemost, http://dx.doi.org/10.1111/j.1538-7836.2010.03894.x

Wong JWH; Schwahn AB; Downard KM, 2010, 'FluTyper-an algorithm for automated typing and subtyping of the influenza virus from high resolution mass spectral data.', BMC Bioinformatics, vol. 11, pp. 266, http://dx.doi.org/10.1186/1471-2105-11-266

Azimi I; Matthias LJ; Center RJ; Wong JWH; Hogg PJ, 2010, 'Disulfide bond that constrains the HIV-1 gp120 V3 domain is cleaved by thioredoxin.', J Biol Chem, vol. 285, pp. 40072 - 40080, http://dx.doi.org/10.1074/jbc.M110.185371

Passam FH; Rahgozar S; Qi M; Raftery MJ; Wong JWH; Tanaka K; Ioannou Y; Zhang JY; Gemmell R; Qi JC, 2010, 'Beta 2 glycoprotein I is a substrate of thiol oxidoreductases.', Blood, vol. 116, pp. 1995 - 1997, http://dx.doi.org/10.1182/blood-2010-02-271494

Passam FH; Rahgozar S; Qi M; Raftery MJ; Wong JWH; Tanaka K; Ioannou Y; Zhang JY; Gemmell R; Qi JC, 2010, 'Redox control of β2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1.', J Thromb Haemost, vol. 8, pp. 1754 - 1762, http://dx.doi.org/10.1111/j.1538-7836.2010.03944.x

Schwahn AB; Wong JWH; Downard KM, 2010, 'Typing of human and animal strains of influenza virus with conserved signature peptides of matrix M1 protein by high resolution mass spectrometry', Journal of Virological Methods, vol. 165, pp. 178 - 185, http://dx.doi.org/10.1016/j.jviromet.2010.01.015

Wong JWH; McRedmond JP; Cagney G, 2009, 'Activity profiling of platelets by chemical proteomics.', Proteomics, vol. 9, pp. 40 - 50, http://dx.doi.org/10.1002/pmic.200800185

Schwahn AB; Wong JWH; Downard KM, 2009, 'Subtyping of the influenza virus by high resolution mass spectrometry.', Anal Chem, vol. 81, pp. 3500 - 3506, http://dx.doi.org/10.1021/ac900026f

Schwahn AB; Wong JWH; Downard KM, 2009, 'Signature peptides of influenza nucleoprotein for the typing and subtyping of the virus by high resolution mass spectrometry.', Analyst, vol. 134, pp. 2253 - 2261, http://dx.doi.org/10.1039/b912234f

Wong JWH; Schwahn AB; Downard KM, 2009, 'ETISEQ--an algorithm for automated elution time ion sequencing of concurrently fragmented peptides for mass spectrometry-based proteomics.', BMC Bioinformatics, vol. 10, pp. 244, http://dx.doi.org/10.1186/1471-2105-10-244

Wong JWH; Sullivan MJ; Cagney G, 2008, 'Computational methods for the comparative quantification of proteins in label-free LCn-MS experiments.', Brief Bioinform, vol. 9, pp. 156 - 165, http://dx.doi.org/10.1093/bib/bbm046

Wong JWH; Sullivan MJ; Cartwright HM; Cagney G, 2007, 'msmsEval: tandem mass spectral quality assignment for high-throughput proteomics.', BMC Bioinformatics, vol. 8, pp. 51, http://dx.doi.org/10.1186/1471-2105-8-51

Wong JWH; Cagney G; Cartwright HM, 2005, 'SpecAlign--processing and alignment of mass spectra datasets.', Bioinformatics, vol. 21, pp. 2088 - 2090, http://dx.doi.org/10.1093/bioinformatics/bti300

Wong JWH; Cartwright HM, 2005, 'Deterministic projection by growing cell structure networks for visualization of high-dimensionality datasets.', J Biomed Inform, vol. 38, pp. 322 - 330, http://dx.doi.org/10.1016/j.jbi.2005.02.002

Wong JWH; Durante C; Cartwright HM, 2005, 'Application of fast Fourier transform cross-correlation for the alignment of large chromatographic and spectral datasets.', Anal Chem, vol. 77, pp. 5655 - 5661, http://dx.doi.org/10.1021/ac050619p

Wong JWH; Downard KM, 2005, 'Performance of the computer algorithm COMPLX for the detection of protein complexes in the mass spectra of simulated biological mixtures.', J Mass Spectrom, vol. 40, pp. 1187 - 1196, http://dx.doi.org/10.1002/jms.894

Wong JWH; Maleknia SD; Downard KM, 2005, 'Hydroxyl radical probe of the calmodulin-melittin complex interface by electrospray ionization mass spectrometry.', J Am Soc Mass Spectrom, vol. 16, pp. 225 - 233, http://dx.doi.org/10.1016/j.jasms.2004.11.009

Zhang S; Srinivasan MV; Zhu H; Wong J, 2004, 'Grouping of visual objects by honeybees.', J Exp Biol, vol. 207, pp. 3289 - 3298, http://dx.doi.org/10.1242/jeb.01155

Maleknia SD; Wong JWH; Downard KM, 2004, 'Photochemical and electrophysical production of radicals on millisecond timescales to probe the structure, dynamics and interactions of proteins.', Photochem Photobiol Sci, vol. 3, pp. 741 - 748, http://dx.doi.org/10.1039/b315904c

Wong JWH; Downard KM, 2003, 'COMPLX: a computer algorithm for the detection of protein-ligand and other macromolecular complexes in mass spectra.', J Mass Spectrom, vol. 38, pp. 573 - 581, http://dx.doi.org/10.1002/jms.474

Wong JWH; Maleknia SD; Downard KM, 2003, 'Study of the ribonuclease-S-protein-peptide complex using a radical probe and electrospray ionization mass spectrometry.', Anal Chem, vol. 75, pp. 1557 - 1563, https://www.ncbi.nlm.nih.gov/pubmed/12705585