Dr Julie Thoms

Field: Cancer Cell Biology

Contact Details

Phone: +61 2 9385 2527
Email: z3283497@unsw.edu.au

Tabs

Main

University role:

Senior Research Associate

Dr Julie Thoms is a Senior Research Associate in the Stem Cell Group at the Lowy Cancer Research Centre. Her primary research interests lie in understanding how gene regulatory networks control stem cell characteristics in normal and malignant cells, with the ultimate aim of using this knowledge to develop targeted cancer therapies. Julie received her PhD from the University of Sydney and then undertook postdoctoral studies under the mentorship of Dr Anthony Bretscher at Cornell University (USA), and Dr Stuart Kauffman at the University of Calgary (Canada). Julie then returned to Sydney to work with Dr John Pimanda at UNSW, where she has used a range of cutting edge genomic techniques to investigate the transcriptional networks controlled by ERG and other key stem cell transcription factors during normal development and in leukemia.

PubMed

History

Member for: 9 years 6 months

Research

Teaching & Supervision

I am available to supervise:

Yes

Areas of supervision:

Honours, ILP, PhD

Supervision keywords:

haematopoietic stem cells

leukemia

gene regulatory networks

epigenetics

Media

LinkedIn:

http://www.linkedin.com/pub/julie-thoms/4/775/8b5

Twitter Account:

https://twitter.com/JulieAThoms

Publications related to this Person

Journal articles

Liu K; Beck D; Thoms JAI; Liu L; Zhao W; Pimanda JE; Zhou X, 2017, 'Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method', Bioinformatics (Oxford, England), vol. 33, pp. 2622 - 2630, http://dx.doi.org/10.1093/bioinformatics/btx280

Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V, 2017, 'Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes', Cell Reports, vol. 20, pp. 572 - 585, http://dx.doi.org/10.1016/j.celrep.2017.06.067

Nasrallah R; Fast EM; Solaimani P; Knezevic K; Eliades A; Patel R; Thambyrajah R; Unnikrishnan A; Thoms J; Beck D, 2016, 'Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes', Blood, vol. 128, pp. 1928 - 1939, http://dx.doi.org/10.1182/blood-2016-02-697870

Unnikrishnan A; Guan YF; Huang Y; Beck D; Thoms JAI; Peirs S; Knezevic K; Ma S; De Walle IV; De Jong IDE, 2016, 'A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network', Nucleic Acids Research, vol. 44, pp. 10644 - 10661, http://dx.doi.org/10.1093/nar/gkw804

Poulos RC; Thoms JAI; Guan YF; Unnikrishnan A; Pimanda JE; Wong JWH, 2016, 'Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif', Cell Reports, vol. 17, pp. 2865 - 2872, http://dx.doi.org/10.1016/j.celrep.2016.11.055

Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, vol. 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15

Huang Y; Thoms JAI; Tursky ML; Knezevic K; Beck D; Chandrakanthan V; Suryani S; Olivier J; Boulton A; Glaros EN, 2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, vol. 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55

Poulos RC; Thoms JAI; Shah A; Beck D; Pimanda JE; Wong JWH, 2015, 'Systematic screening of promoter regions pinpoints functional cis-regulatory mutations in a cutaneous melanoma genome', Molecular Cancer Research, vol. 13, pp. 1218 - 1226, http://dx.doi.org/10.1158/1541-7786.MCR-15-0146

Marks-Bluth J; Khanna A; Chandrakanthan V; Thoms J; Bee T; Eich C; Kang YC; Knezevic K; Qiao Q; Fitch S, 2015, 'SMAD1 and SMAD5 expression is coordinately regulated by FLI1 and GATA2 during endothelial development', Molecular and Cellular Biology, vol. 35, pp. 2165 - 2172, http://dx.doi.org/10.1128/MCB.00239-15

Tursky ML; Beck D; Thoms JAI; Huang Y; Kumari A; Unnikrishnan A; Knezevic K; Evans K; Richards LA; Lee E, 2015, 'Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias', Leukemia, vol. 29, pp. 819 - 827, http://dx.doi.org/10.1038/leu.2014.299

Jing D; Bhadri VA; Beck D; Thoms JAI; Yakob NA; Wong JWH; Knezevic K; Pimanda JE; Lock RB, 2015, 'Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells', Blood, vol. 125, pp. 273 - 283, http://dx.doi.org/10.1182/blood-2014-05-576470

Perera D; Chacon D; Thoms JA; Poulos RC; Shlien A; Beck D; Campbell PJ; Pimanda JE; Wong JW, 2014, 'Oncocis: Annotation of cis-regulatory mutations in cancer', Genome Biology, vol. 15, http://dx.doi.org/10.1186/s13059-014-0485-0

Beck D; Thoms JAI; Perera D; Schütte J; Unnikrishnan A; Knezevic K; Kinston SJ; Wilson NK; O'Brien TA; Göttgens B, 2013, 'Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes', Blood, vol. 122, pp. e12 - e22, http://dx.doi.org/10.1182/blood-2013-03-490425

Diffner E; Beck D; Gudgin E; Thoms JAI; Knezevic K; Pridans C; Foster S; Goode D; Lim WK; Boelen L, 2013, 'Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia', Blood, vol. 121, pp. 2289 - 2300, http://dx.doi.org/10.1182/blood-2012-07-446120

Oram SH; Thoms J; Sive J; Calero-Nieto FJ; Kinston SJ; Schuette J; Knezevic K; Lock RB; Pimanda JE; Gottgens B, 2013, 'Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia', Leukemia, vol. 27, pp. 1348 - 1357, http://dx.doi.org/10.1038/leu.2013.2

Thoms JAI; Birger Y; Foster S; Knezevic K; Kirschenbaum Y; Chandrakanthan V; Jonquieres G; Spensberger D; Wong JW; Oram SH, 2011, 'ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer', Blood, vol. 117, pp. 7079 - 7089, http://dx.doi.org/10.1182/blood-2010-12-317990

Oram SH; Thoms JAI; Pridans C; Janes ME; Kinston SJ; Anand S; Landry JR; Lock RB; Jayaraman PS; Huntly BJ, 2010, 'A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients', Oncogene, vol. 29, pp. 5796 - 5808, http://dx.doi.org/10.1038/onc.2010.320

Thoms JAI; Loch HM; Bamburg JR; Gunning PW; Weinberger RP, 2008, 'A tropomyosin 1 induced defect in cytokinesis can be rescued by elevated expression of cofilin', Cell Motility and the Cytoskeleton, vol. 65, pp. 979 - 990, http://dx.doi.org/10.1002/cm.20320

Percival JM; Hughes JAI; Brown DL; Schevzov G; Heimann K; Vrhovski B; Bryce N; Stow JL; Gunning PW, 2004, 'Targeting of a Tropomyosin Isoform to Short Microfilaments Associated with the Golgi Complex', Molecular Biology of the Cell, vol. 15, pp. 268 - 280, http://dx.doi.org/10.1091/mbc.E03-03-0176

Hughes JAI; Weckert HA; Van Holst Pellekaan C; Benson EM; Dunn IS, 2003, 'Translocations into human chromosome 14 JH region: Factors influencing downstream abortive immunoglobulin class switching', Molecular Immunology, vol. 40, pp. 573 - 583, http://dx.doi.org/10.1016/j.molimm.2003.09.001

McGowan EM; Weinberger RP; Graham JD; Hill HD; Hughes JAI; O'Neill GM; Clarke CL, 2003, 'Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels', Journal of Molecular Endocrinology, vol. 31, pp. 241 - 253, http://dx.doi.org/10.1677/jme.0.0310241

Yager ML; Hughes JAI; Lovicu FJ; Gunning PW; Weinberger RP; O'Neill GM, 2003, 'Functional analysis of the actin-binding protein, tropomyosin I, in neuroblastoma', British Journal of Cancer, vol. 89, pp. 860 - 863, http://dx.doi.org/10.1038/sj.bjc.6601201

Hughes JAI; Cooke-Yarborough CM; Chadwick NC; Schevzov G; Arbuckle SM; Gunning P; Weinberger RP, 2003, 'High-molecular-weight tropomyosins localize to the contractile rings of dividing CNS cells but are absent from malignant pediatric and adult CNS tumors', GLIA, vol. 42, pp. 25 - 35, http://dx.doi.org/10.1002/glia.10174

Weckert HA; Hughes JAI; Benson EM; Dunn IS, 2000, 'Quantifiable analysis of human immunoglobulin heavy chain class-switch recombination to all isotypes', Journal of Immunological Methods, vol. 233, pp. 141 - 158, http://dx.doi.org/10.1016/S0022-1759(99)00132-5

Conference Papers

Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J, 2016, 'Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes', Ferrata Storti Foundation, Copenhagen, Denmark, pp. 157 - 158, presented at 21st Congress Of The European Hematology Association (EHA), Copenhagen, Denmark, 09 - 12 June 2016, https://synapse.mskcc.org/synapse/works/97032

Avellino R; Havermans M; Erpelinck C; Sanders M; Groeschel S; Vandewerken H; Hoogenboezem RM; Rombouts E; Van Lom K; Van Strien P, 2015, 'A Tissue-Specific Transcriptional Element for C/ebpa Is Required for HSC Maintenance and Neutrophil Development', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, presented at 57th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 05 - 08 December 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368019001053&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML, 2015, 'An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, presented at 57th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 05 - 08 December 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368019002147&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Unnikrishnan A; Beck D; Verma A; Richards LA; Thoms JAI; Kumari A; Galbraith S; Kulasekararaj A; Tobiasson M; Woll PS, 2014, 'Identification of a Prognostic Gene Expression Signature for AZA Response in MDS and CMML Patients', in BLOOD, AMER SOC HEMATOLOGY, San Francisco, CA, presented at 56th Annual Meeting of the American-Society-of-Hematology, San Francisco, CA, 06 - 09 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349243501166&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Beck D; Thoms J; Perera D; Unnikrishnan A; Knezevic K; O'Brien T; Gottgens B; Wong J; Pimanda J, 2013, 'GENOME-WIDE ANALYSIS OF TRANSCRIPTIONAL REGULATORS IN HUMAN HSCS REVEALS A DENSELY INTERCONNECTED NETWORK OF CODING AND NON-CODING GENES', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Vienna, AUSTRIA, pp. S17 - S17, presented at 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), Vienna, AUSTRIA, 22 - 25 August 2013, http://dx.doi.org/10.1016/j.exphem.2013.05.063

Conference Presentations

Diffner E; Beck D; Gudgin E; Thoms J; Knezevic K; Pridans C; Foster S; Goode D; Lim WK; Boelen L, 2012, 'Activity of a Heptad of Transcription Factors Is Associated with Stem Cell Programs and Clinical Outcome in Acute Myeloid Leukaemia', in BLOOD, AMER SOC HEMATOLOGY, Atlanta, GA, Vol. 120, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta, GA, 08 - 11 December 2012, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000313838906132&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J, 2016, 'INTEGRATIVE GENOMICS IDENTIFIES THE MOLECULAR BASIS OF RESISTANCE TO AZACITIDINE THERAPY IN MYELODYSPLASTIC SYNDROMES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, Copenhagen, DENMARK, Vol. 101, pp. 157 - 158, presented at 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, 09 - 12 June 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600349&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Beck D; Thoms J; Palu C; Herold T; Shah A; Olivier J; Boelen L; Huang Y; Chacon D; Brown A, 2016, 'INTEGRATIVE ANALYSIS OF LINCRNA EXPRESSION IN 922 ACUTE MYELOID LEUKEMIA PATIENTS REVEALS MULTIPLE PROGNOSTIC GENE SIGNATURES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, Copenhagen, DENMARK, Vol. 101, pp. 208 - 209, presented at 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, 09 - 12 June 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600457&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1