Dr Natalie Kwai

Contact Details

Email: natalie.kwai@unsw.edu.au

Tabs

Main

University role:

Associate Lecturer

My research interests cover neurodegeneration in metabolic disease, its pathogenesis, functional outcomes and protective avenues. Investigations through my PhD and postdoctoral studies have utilised cutting edge neurophysiology techniques, namely, axonal excitability techniques to delineate the underlying biophysical properties of nerves in patients with diabetes. My previous work indicated subclinical abnormalities in nerve function in patients with diabetes in the absence of neuropathy, further indicating that these abnormalities were not related to average glycaemia. Subsequent investigations revealed that these changes were related to the use of different modalities of insulin delivery, namely insulin pump therapy and further studies indicating that these alterations were related to glycaemic variability which is presently the subject of a Phase II Clinical Trial my group are undertaking in collaboration with Industry (Insulin Pump therapy for Reducing Diabetic complications ( InsPyReD ) study, ANZCRTN:12617000124336)

History

Member for: 8 years 4 months

Groups:

Neuroscience Research Group

Research

Publications related to this Person

Journal articles

Yan A; Issar T; Tummanapalli SS; Markoulli M; Kwai NCG; Poynten AM; Krishnan AV, 2019, 'Relationship between corneal confocal microscopy and markers of peripheral nerve structure and function in Type 2 diabetes', Diabetic Medicine, http://dx.doi.org/10.1111/dme.13952

Borire AA; Issar T; Kwai NC; Visser LH; Simon NG; Poynten AM; Kiernan MC; Krishnan AV, 2018, 'Correlation between markers of peripheral nerve function and structure in type 1 diabetes', Diabetes/Metabolism Research and Reviews, vol. 34, http://dx.doi.org/10.1002/dmrr.3028

Issar T; Arnold R; Kwai NCG; Pussell BA; Endre ZH; Poynten AM; Kiernan MC; Krishnan AV, 2018, 'The utility of the Total Neuropathy Score as an instrument to assess neuropathy severity in chronic kidney disease: A validation study', Clinical Neurophysiology, vol. 129, pp. 889 - 894, http://dx.doi.org/10.1016/j.clinph.2018.02.120

Eviston TJ; Chong LSH; Kwai NCG; Clark JR; Krishnan AV, 2018, 'Altered axonal excitability properties in facial palsy', Muscle and Nerve, vol. 57, pp. 268 - 272, http://dx.doi.org/10.1002/mus.25677

Borire AA; Arnold R; Pussell BA; Kwai NC; Visser LH; Simon NG; Kiernan MC; Krishnan AV, 2018, 'Effects of hemodialysis on intraneural blood flow in end-stage kidney disease', Muscle and Nerve, vol. 57, pp. 287 - 293, http://dx.doi.org/10.1002/mus.25704

Huynh W; Kwai N; Arnold R; Krishnan AV; Lin CSY; Vucic S; Kiernan MC, 2017, 'The effect of diabetes on cortical function in stroke: Implications for poststroke plasticity', Diabetes, vol. 66, pp. 1661 - 1670, http://dx.doi.org/10.2337/db16-0961

Borire AA; Arnold R; Pussell BA; Kwai NC; Visser LH; Padua L; Simon NG; Kiernan MC; Krishnan AV, 2017, 'Haemodialysis alters peripheral nerve morphology in end-stage kidney disease', Clinical Neurophysiology, vol. 128, pp. 281 - 286, http://dx.doi.org/10.1016/j.clinph.2016.09.010

Kwai NCG; Arnold R; Poynten AM; Krishnan AV, 2016, 'Association between glycemic variability and peripheral nerve dysfunction in type 1 diabetes', Muscle and Nerve, vol. 54, pp. 967 - 969, http://dx.doi.org/10.1002/mus.25274

Kwai NCG; Nigole W; Poynten AM; Brown C; Krishnan AV, 2016, 'The relationship between dyslipidemia and acute axonal function in type 2 diabetes mellitus in vivo', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0153389

Kwai NCG; Arnold R; Poynten AM; Howells J; Kiernan MC; Lin CSY; Krishnan AV, 2016, 'In vivo evidence of reduced nodal and paranodal conductances in type 1 diabetes', Clinical Neurophysiology, vol. 127, pp. 1700 - 1706, http://dx.doi.org/10.1016/j.clinph.2015.11.047

Kwai N; Arnold R; Poynten AM; Lin CSY; Kiernan MC; Krishnan AV, 2015, 'Continuous subcutaneous insulin infusion preserves axonal function in type 1 diabetes mellitus', Diabetes/Metabolism Research and Reviews, vol. 31, pp. 175 - 182, http://dx.doi.org/10.1002/dmrr.2583

Arnold R; Kwai NCG; Krishnan AV, 2013, 'Mechanisms of axonal dysfunction in diabetic and uraemic neuropathies', Clinical Neurophysiology, vol. 124, pp. 2079 - 2090, http://dx.doi.org/10.1016/j.clinph.2013.04.012

Arnold R; Kwai N; Lin CSY; Poynten AM; Kiernan MC; Krishnan AV, 2013, 'Axonal dysfunction prior to neuropathy onset in type 1 diabetes', Diabetes/Metabolism Research and Reviews, vol. 29, pp. 53 - 59, http://dx.doi.org/10.1002/dmrr.2360

Kwai NCG; Arnold R; Wickremaarachchi C; Lin CSY; Poynten AM; Kiernan MC; Krishnan AV, 2013, 'Effects of axonal ion channel dysfunction on quality of life in type 2 diabetes', Diabetes Care, vol. 36, pp. 1272 - 1277, http://dx.doi.org/10.2337/dc12-1310

Sung JY; Park SB; Liu YT; Kwai N; Arnold R; Krishnan AV; Lin CSY, 2012, 'Progressive axonal dysfunction precedes development of neuropathy in type 2 diabetes', Diabetes, vol. 61, pp. 1592 - 1598, http://dx.doi.org/10.2337/db11-1509

Conference Papers

Arnold R; Kwai N; Pussell BA; Lin CS-Y; Kiernan MC; Krishnan AV, 2014, 'Effects of neuropathy on physical function and quality of life in moderate severity chronic kidney disease', in Clinical Neurophysiology, ANZAN Clinical Neurophysiology Workshop, Gold Coast, Queensland, pp. e4 - e4, presented at ANZAN Clinical Neurophysiology Workshop, Gold Coast, Queensland, 29 September - 02 October 2013, http://dx.doi.org/10.1016/j.clinph.2013.10.031

Kwaia N; Arnold R; Poynten A; Lin C; Kiernan MC; Krishnan A, 2014, 'Insulin pump therapy in type 1 diabetes: Potential to be neuroprotective', in Clinical Neurophysiology, http://dx.doi.org/10.1016/j.clinph.2013.10.024

Arnold R; Kwai N; Poynten A; Lin CS-Y; Kiernan MC; Krishnan AV, 2012, 'Altered axonal excitability in asymptomatic type 1 diabetic patients', in Clinical Neurophysiology, ANZAN Clinical Neurophysiology Workshop, Gold Coast, Queensland, pp. e73 - e73, presented at ANZAN Clinical Neurophysiology Workshop, Gold Coast, Queensland, 02 - 05 October 2011, http://dx.doi.org/10.1016/j.clinph.2011.11.023

Kwai N; Arnold R; Wickremaarachchi, C; Poynten AM; Lin C; Kiernan MC; Krishnan A, 2011, 'Neurophysiological parameters and impaired quality of life in diabetic peripheral neuropathy', Australian Diabetes Society Scientific Meeting 2011, Perth, presented at Australian Diabetes Society Scientific Meeting 2011, Perth, 31 August 2011

Lin CS-Y; Sung JY; Park SB; Arnold R; Kwai N; Krishnan AV, 2011, 'Pre-diabetic neuropathy: Axonal dysfunction evident prior to clinical neuropathy', in Journal of the Peripheral Nervous System, Wiley, Potomac, Unites States of America, presented at Peripheral Nerve Society Meeting, Potomac, Unites States of America, 25 - 29 September 2011, http://dx.doi.org/10.1111/j.1529-8027.2011.00335.x

Arnold R; kwai N; Lin, C.S-Y; Kiernan, MC; Krishnan, AV, 2011, 'Evidence for distinct patterns of axonal excitability between type 1 and type 2 diabetic nerves', in Journal of the Peripheral Nervous System, Wiley, Potomac, Unites States of America, pp. S5 - S5, presented at Peripheral Nerve Society Meeting, Potomac, Unites States of America, 25 - 29 September 2011, http://dx.doi.org/10.1111/j.1529-8027.2011.00335.x

Prince of Wales Clinical School, UNSW Medicine NSW 2052 Australia | Authorised by Head of School | CRICOS Provider Code: 00098G | ABN: 57 195 873 179 Page last updated: Tuesday 20 August 2019

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