Dr Natalie Kwai

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University role:

Adjunct Lecturer

My research interests cover neurodegeneration in metabolic disease, its pathogenesis, functional outcomes and protective avenues. Investigations through my PhD and postdoctoral studies have utilised cutting edge neurophysiology techniques, namely, axonal excitability techniques to delineate the underlying biophysical properties of nerves in patients with diabetes. My previous work indicated subclinical abnormalities in nerve function in patients with diabetes in the absence of neuropathy, further indicating that these abnormalities were not related to average glycaemia. Subsequent investigations revealed that these changes were related to the use of different modalities of insulin delivery, namely insulin pump therapy and further studies indicating that these alterations were related to glycaemic variability which is presently the subject of a Phase II Clinical Trial my group are undertaking in collaboration with Industry (Insulin Pump therapy for Reducing Diabetic complications ( InsPyReD ) study, ANZCRTN:12617000124336)

History

Member for: 11 years 3 months

Groups:

Neuroscience Research Group

Research

Publications related to this Person

Journal articles

Issar T; Tummanapalli SS; Kwai NCG; Chiang JCB; Arnold R; Poynten AM; Markoulli M; Krishnan AV, 2020, 'Associations between acute glucose control and peripheral nerve structure and function in type 1 diabetes', Diabetic Medicine, vol. 37, pp. 1553 - 1560, http://dx.doi.org/10.1111/dme.14306

Tummanapalli SS; Issar T; Kwai N; Pisarcikova J; Poynten AM; Krishnan AV; Willcox MDP; Markoulli M, 2020, 'A Comparative Study on the Diagnostic Utility of Corneal Confocal Microscopy and Tear Neuromediator Levels in Diabetic Peripheral Neuropathy', Current Eye Research, vol. 45, pp. 921 - 930, http://dx.doi.org/10.1080/02713683.2019.1705984

Tummanapalli SS; Willcox MDP; Issar T; Kwai N; Poynten AM; Krishnan AV; Pisarcikova J; Markoulli M, 2020, 'The Effect of Age, Gender and Body Mass Index on Tear Film Neuromediators and Corneal Nerves', Current Eye Research, vol. 45, pp. 411 - 418, http://dx.doi.org/10.1080/02713683.2019.1666998

Issar T; Yan A; Kwai NCG; Poynten AM; Borire AA; Arnold R; Krishnan AV, 2020, 'Altered peripheral nerve structure and function in latent autoimmune diabetes in adults', Diabetes/Metabolism Research and Reviews, vol. 36, pp. e3260, http://dx.doi.org/10.1002/dmrr.3260

Tummanapalli SS; Issar T; Kwai N; Poynten A; Krishnan AV; Willcox M; Markoulli M, 2020, 'Erratum to ‘Association of corneal nerve loss with markers of axonal ion channel dysfunction in type 1 diabetes’. (Clinical Neurophysiology (2020) 131(1) (145–154), (S1388245719312726), (10.1016/j.clinph.2019.09.029))', Clinical Neurophysiology, vol. 131, pp. 780, http://dx.doi.org/10.1016/j.clinph.2020.01.001

Yan A; Issar T; Tummanapalli SS; Markoulli M; Kwai NCG; Poynten AM; Krishnan AV, 2020, 'Relationship between corneal confocal microscopy and markers of peripheral nerve structure and function in Type 2 diabetes', Diabetic Medicine, vol. 37, pp. 326 - 334, http://dx.doi.org/10.1111/dme.13952

Borire AA; Issar T; Kwai NC; Visser LH; Simon NG; Poynten AM; Kiernan MC; Krishnan AV, 2020, 'Sonographic assessment of nerve blood flow in diabetic neuropathy', Diabetic Medicine, vol. 37, pp. 343 - 349, http://dx.doi.org/10.1111/dme.14085

Tummanapalli SS; Issar T; Kwai N; Poynten A; Krishnan AV; Willcox M; Markoulli M, 2020, 'Association of corneal nerve loss with markers of axonal ion channel dysfunction in type 1 diabetes', Clinical Neurophysiology, vol. 131, pp. 145 - 154, http://dx.doi.org/10.1016/j.clinph.2019.09.029

Tummanapalli SS; Issar T; Yan A; Kwai N; Poynten AM; Krishnan AV; Willcox MDP; Markoulli M, 2020, 'Corneal nerve fiber loss in diabetes with chronic kidney disease', Ocular Surface, vol. 18, pp. 178 - 185, http://dx.doi.org/10.1016/j.jtos.2019.11.010

Issar T; Arnold R; Kwai NCG; Walker S; Yan A; Borire AA; Poynten AM; Pussell BA; Endre ZH; Kiernan MC; Krishnan AV, 2019, 'Relative contributions of diabetes and chronic kidney disease to neuropathy development in diabetic nephropathy patients', Clinical Neurophysiology, vol. 130, pp. 2088 - 2095, http://dx.doi.org/10.1016/j.clinph.2019.08.005

Tummanapalli SS; Willcox MDP; Issar T; Yan A; Pisarcikova J; Kwai N; Poynten AM; Krishnan AV; Markoulli M, 2019, 'Tear film substance P: A potential biomarker for diabetic peripheral neuropathy', Ocular Surface, vol. 17, pp. 690 - 698, http://dx.doi.org/10.1016/j.jtos.2019.08.010

Borire A; Issar T; Kwai N; Visser L; Poynten A; Simon N; Kiernan M; Krishnan A, 2019, '025 The utility of nerve blood flow in the assessment of peripheral neuropathy', Journal of Neurology, Neurosurgery & Psychiatry, vol. 90, pp. A9.2 - A9, http://dx.doi.org/10.1136/jnnp-2019-anzan.24

Borire AA; Issar T; Kwai NC; Visser LH; Simon NG; Poynten AM; Kiernan MC; Krishnan AV, 2018, 'Correlation between markers of peripheral nerve function and structure in type 1 diabetes', Diabetes/Metabolism Research and Reviews, vol. 34, http://dx.doi.org/10.1002/dmrr.3028

Issar T; Arnold R; Kwai NCG; Pussell BA; Endre ZH; Poynten AM; Kiernan MC; Krishnan AV, 2018, 'The utility of the Total Neuropathy Score as an instrument to assess neuropathy severity in chronic kidney disease: A validation study', Clinical Neurophysiology, vol. 129, pp. 889 - 894, http://dx.doi.org/10.1016/j.clinph.2018.02.120

Borire AA; Arnold R; Pussell BA; Kwai NC; Visser LH; Simon NG; Kiernan MC; Krishnan AV, 2018, 'Effects of hemodialysis on intraneural blood flow in end-stage kidney disease', Muscle and Nerve, vol. 57, pp. 287 - 293, http://dx.doi.org/10.1002/mus.25704

Eviston TJ; Chong LSH; Kwai NCG; Clark JR; Krishnan AV, 2018, 'Altered axonal excitability properties in facial palsy', Muscle and Nerve, vol. 57, pp. 268 - 272, http://dx.doi.org/10.1002/mus.25677

Huynh W; Kwai N; Arnold R; Krishnan AV; Lin CSY; Vucic S; Kiernan MC, 2017, 'The effect of diabetes on cortical function in stroke: Implications for poststroke plasticity', Diabetes, vol. 66, pp. 1661 - 1670, http://dx.doi.org/10.2337/db16-0961

Borire AA; Arnold R; Pussell BA; Kwai NC; Visser LH; Padua L; Simon NG; Kiernan MC; Krishnan AV, 2017, 'Haemodialysis alters peripheral nerve morphology in end-stage kidney disease', Clinical Neurophysiology, vol. 128, pp. 281 - 286, http://dx.doi.org/10.1016/j.clinph.2016.09.010

Borire A; Issar T; Kwai N; Krishnan A, 2017, 'Association between peripheral nerve function and structure in human diabetic nerves', Journal of Neurology, Neurosurgery & Psychiatry, vol. 88, pp. e1.1 - e1, http://dx.doi.org/10.1136/jnnp-2017-316074

Kwai NCG; Arnold R; Poynten AM; Krishnan AV, 2016, 'Association between glycemic variability and peripheral nerve dysfunction in type 1 diabetes', Muscle and Nerve, vol. 54, pp. 967 - 969, http://dx.doi.org/10.1002/mus.25274

Kwai NCG; Nigole W; Poynten AM; Brown C; Krishnan AV, 2016, 'The relationship between dyslipidemia and acute axonal function in type 2 diabetes mellitus in vivo', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0153389

Kwai NCG; Arnold R; Poynten AM; Howells J; Kiernan MC; Lin CSY; Krishnan AV, 2016, 'In vivo evidence of reduced nodal and paranodal conductances in type 1 diabetes', Clinical Neurophysiology, vol. 127, pp. 1700 - 1706, http://dx.doi.org/10.1016/j.clinph.2015.11.047

Kwai N; Arnold R; Poynten AM; Lin CSY; Kiernan MC; Krishnan AV, 2015, 'Continuous subcutaneous insulin infusion preserves axonal function in type 1 diabetes mellitus', Diabetes/Metabolism Research and Reviews, vol. 31, pp. 175 - 182, http://dx.doi.org/10.1002/dmrr.2583

Arnold R; Kwai NCG; Krishnan AV, 2013, 'Mechanisms of axonal dysfunction in diabetic and uraemic neuropathies', Clinical Neurophysiology, vol. 124, pp. 2079 - 2090, http://dx.doi.org/10.1016/j.clinph.2013.04.012

Kwai NCG; Arnold R; Wickremaarachchi C; Lin CS-Y; Poynten AM; Kiernan MC; Krishnan AV, 2013, 'Effects of Axonal Ion-Channel Dysfunction on Quality of Life in Type 2 Diabetes.', Diabetes Care, vol. 36, pp. 1272 - 1277, http://dx.doi.org/10.2337/dc12-1310

Arnold R; Kwai NCG; Lin CS-Y; Poynten AM; Kiernan MC; Krishnan AV, 2013, 'Axonal dysfunction prior to neuropathy onset in type 1 diabetes', Diabetes - Metabolism Research and Reviews, vol. 29, pp. 53 - 59, http://dx.doi.org/10.1002/dmrr.2360

Sung J; Park SB; Liu Y; Kwai N; Arnold R; Krishnan AV; Lin CS-Y, 2012, 'Progressive axonal dysfunction precedes development of neuropathy in type 2 Diabetes.', Diabetes, vol. 61, pp. 1592 - 1598, http://dx.doi.org/10.2337/db11-1509

Kwai N; Arnold R; Wickrema C; Poynten A; Kiernan M; Krishnan A, 2012, '20. Effects of altered axonal biophysical properties on quality of life in diabetic peripheral neuropathy', Clinical Neurophysiology, vol. 123, pp. e75 - e75, http://dx.doi.org/10.1016/j.clinph.2011.11.029

Conference Papers

Conference Presentations

Broderick C; Engel A; Hardy L; Kwai N; Van Doorn N; Ward R; Parmenter B, 2020, 'Intervention for Fundamental Motor Skills And Physical Activity In Pre-schoolers: A Cluster-randomized Controlled Trial.', presented at 2020 American College of Sports Medicine Annual Meeting, 27 May 2020 - 30 May 2020