Ms Kathy Knezevic

Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'Pdgf-ab and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113

Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P; Tunningley R; Whittle B; Yeung AWS; Chandrakanthan V; Hesson L; Chen V; Wong JWH; Purton LE; Ward RL; Thomas SR; Pimanda JE, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, vol. 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15

Nasrallah R; Knezevic K; Thai T; Thomas SR; Göttgens B; Lacaud G; Kouskoff V; Pimanda JE, 2015, 'Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis', Biology Open, vol. 4, pp. 819 - 829, http://dx.doi.org/10.1242/bio.011494

Tursky ML; Beck D; Thoms JAI; Huang Y; Kumari A; Unnikrishnan A; Knezevic K; Evans K; Richards LA; Lee E; Morris J; Goldberg L; Izraeli S; Wong JWH; Olivier J; Lock RB; MacKenzie KL; Pimanda JE, 2015, 'Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias', Leukemia, vol. 29, pp. 819 - 827, http://dx.doi.org/10.1038/leu.2014.299

Marks-Bluth J; Khanna A; Chandrakanthan V; Thoms J; Bee T; Eich C; Kang YC; Knezevic K; Qiao Q; Fitch S; Oxburgh L; Ottersbach K; Dzierzak E; de Bruijn MFTR; Pimanda JE, 2015, 'SMAD1 and SMAD5 expression is coordinately regulated by FLI1 and GATA2 during endothelial development', Molecular and Cellular Biology, vol. 35, pp. 2165 - 2172, http://dx.doi.org/10.1128/MCB.00239-15

Jing RBAB, 2015, 'Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells', Blood, vol. 125, pp. 273 - 283, http://dx.doi.org/10.1182/blood-2014-05-576470

Diffner E; Beck D; Gudgin E; Thoms JAI; Knezevic K; Pridans C; Foster S; Goode D; Khong Lim W; Boelen L; Metzeler KH; Micklem G; Bohlander SK; Buske C; Burnett A; Ottersbach K; Vassiliou GS; Olivier J; Wong JWH; Gottgens B; Huntly BJ; Pimanda JE, 2014, 'Erratum: Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia (Blood (2013) 121:12 (2289-2300))', Blood, vol. 123, pp. 2901, http://dx.doi.org/10.1182/blood-2014-03-564831

Goldberg L; Tijssen MR; Birger Y; Hannah RL; Kinston SJ; Schütte J; Beck D; Knezevic K; Schiby G; Jacob-Hirsch J; Biran A; Kloog Y; Marcucci G; Bloomfield CD; Aplan PD; Pimanda JE; Göttgens B; Izraeli S, 2013, 'Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia', Blood, vol. 122, pp. 2694 - 2703, http://dx.doi.org/10.1182/blood-2013-01-477133

Beck D; Thoms JAI; Perera D; Schütte J; Unnikrishnan A; Knezevic K; Kinston SJ; Wilson NK; O'Brien TA; Göttgens B; Wong JWH; Pimanda JE, 2013, 'Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes', Blood, vol. 122, pp. e12 - e22, http://dx.doi.org/10.1182/blood-2013-03-490425

Oram SH; Thoms J; Sive J; Calero-Nieto FJ; Kinston SJ; Schuette J; Knezevic K; Lock RB; Pimanda JE; Gottgens B, 2013, 'Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia', Leukemia, vol. 27, pp. 1348 - 1357, http://dx.doi.org/10.1038/leu.2013.2

Diffner E; Beck D; Gudgin E; Thoms JA; Knezevic K; Pridans C; Foster S; Goode D; Lim WK; boelen L; Metzeler KH; Micklem G; Bohlander SK; Buske C; Burnett A; Ottersbach K; Vassiliou GS; Olivier J; Wong JWH; Goettgens B; Huntly BJ; Pimanda JE, 2013, 'Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia', Blood, vol. 121, pp. 2289 - 2300, http://dx.doi.org/10.1182/blood-2012-07-446120

Pereira LA; Wong MS; Mossmann AK; Sourris K; Janes ME; Knezevic K; Hirst CE; Lim S; Pimanda JE; Stanley E; Elefanty A, 2012, 'Pdgfrá and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells', Steam cell research, vol. 8, pp. 165 - 179, http://dx.doi.org/10.1016/j.scr.2011.09.007

Thoms JAI; Birger Y; Foster S; Knezevic K; Kirshenbaum Y; Chandrakanthan V; Jonquieres G; Spensberger D; Wong JW; Oram SH; Kinston SJ; Groner Y; Lock RB; MacKenzie KL; Gottgens B; Izraeli S; Pimanda JE, 2011, 'ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer', Blood, vol. 117, pp. 7079 - 7089, http://dx.doi.org/10.1182/blood-2010-12-317990

Knezevic K; Wilson N; Bee T; Janes M; Kinston SJ; Polderdijk S; Kolb-Kokocinski A; Ottersbach K; Pencovich N; Groner Y; De bruijn M; Gottgens B; Pimanda JE, 2011, 'A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis', Molecular and Cellular Biology, vol. 31, pp. 2817 - 2826, http://dx.doi.org/10.1128/MCB.01305-10

Taoudi S; Bee T; Hilton A; Knezevic K; Scott J; Scott J; Willson TA; Collin C; Thomas T; Voss AK; Kile BT; Alexander WS; Pimanda JE; Hilton DJ, 2011, 'ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification', Genes and Development, vol. 25, pp. 251 - 262, http://dx.doi.org/10.1101/gad.2009211

Landry J; Bonadies N; Kinston S; Knezevic K; Wilson N; Oram SH; Janes M; Piltz S; Hammett M; Carter J; Hamilton T; Donaldson I; Lacaud G; Frampton J; Follows G; Kouskoff V; Gottgens B, 2009, 'Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors', Blood, vol. 113, pp. 5783 - 5792, http://dx.doi.org/10.1182/blood-2008-11-187757

Pimanda JE; Chan W; Wilson N; Smith A; Kinston S; Knezevic K; Janes M; Landry J; Kolb-Kokocinski A; Frampton J; Tannahill D; Ottersbach K; Follows G; Goettgens B; Lacaud G; Kouskoff V, 2008, 'Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code', Blood, vol. 112, pp. 4512 - 4522, http://dx.doi.org/10.1182/blood-2008-05-157560

Landry J; Kinston S; Knezevic K; De bruijn M; Wilson N; Nottingham W; Peitz M; Edenhofer F; Pimanda JE; Ottersbach K; Gottgens B, 2008, 'Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.', Blood, vol. 111, pp. 3005 - 3014, http://dx.doi.org/10.1182/blood-2007-07-098830

Chan W; Follows G; Lacaud G; Pimanda JE; Landry J; Kinston S; Knezevic K; Piltz S; Donaldson I; Gambardella L; Sablitzky F; Green AR; Kouskoff V; Gottgens B, 2007, 'The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.', Blood, vol. 109, pp. 1908 - 1916, http://dx.doi.org/10.1182/blood-2006-05-023226

Pimanda JE; Ottersbach K; Knezevic K; Kinston S; Chan W; Wilson N; Landry J; Kolb-Kokocinski A; Green AR; Tannahill D; Gottgens B, 2007, 'The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity.', Proceedings of the National Academy of Sciences of the United States of America, vol. 104, pp. 840 - 845, http://dx.doi.org/10.1073/pnas.0607196104

Pimanda JE; Ottersbach K; Knezevic K; Kinston S; Chan W; Wilson N; Landry J; Wood A; Kolb-Kokocinski A; Green AR; Tannahill D; Lacaud G; Kouskoff V; Gottgens B, 2007, 'Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development', Proceedings of the National Academy of Sciences of the United States of America, vol. 104, pp. 17692 - 17697, http://dx.doi.org/10.1073/pnas.0707045104

Micallef S; Janes M; Knezevic K; Davis R; Elefanty A; Stanley E, 2005, 'Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells.', Diabetes, vol. 54, pp. 301 - 305, http://dx.doi.org/10.2337/diabetes.54.2.301

Donaldson I; Chapman M; Kinston S; Landry J; Knezevic K; Peitz M; Green AR; Gottgens B; Buckley N, 2005, 'Genome-wide identification of cis-regulatory sequences controlling blood and endothelial development.', Human Molecular Genetics, vol. 14, pp. 595 - 601, http://dx.doi.org/10.1093/hmg/ddi056

Landry J; Kinston S; Knezevic K; Donaldson I; Green AR; Gottgens B, 2005, 'Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells', Blood, vol. 106, pp. 2680 - 2687, http://dx.doi.org/10.1182/blood-2004-12-4755

Gottgens B; Broccardo C; Sanchez M; Deveaux S; Murphy G; Gothert J; Kotsopoulou E; Kinston S; Delaney L; Piltz S; Barton L; Knezevic K; Erber W; Begley C; Frampton J; Green AR, 2004, 'The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1.', Molecular and Cellular Biology, vol. 24, pp. 1870 - 1883, http://dx.doi.org/10.1128/MCB.24.5.1870-1883.2004