Interactions between Transcription Factor Networks and Cell Signaling Pathways during Early Blood Development

Project supporters:

  • NH&MRC Project Grant “Investigating Transcriptional Determinants of Embryonic Haematopoiesis”

Research Project Main Image

Project members:

Project main description:

In the embryo, blood stem cells develop either directly from an immature precursor or from endothelial cells that line the inner surface of blood vessels. In the absence of a protein called SMAD1 there is failure of blood development despite normal endothelial cell development. Here we will investigate the molecular consequences that accompany SMAD1 absence in endothelial cells and their failure to form blood cells. This knowledge will benefit attempts to manufacture blood stem cells for therapy.

Project members
Chief Investigator - Professor John Pimanda
Professor Marella de Bruijn (Oxford)

Project supporters:

  • NH&MRC Project Grant “Investigating Transcriptional Determinants of Embryonic Haematopoiesis”